Tuesday, 6 March 2018

Does contraception lead to depression?

Roger Watson, Editor

The aim of this study was: 'to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database'. The study was conducted in Japan and the article, which is published in Nursing Open is authored by Horibe et al. (2017). 

The total number of Food and Drug Administration Adverse Event Reporting System System (FAERS) reports analysed was 6,157,897 of which 253 reported postpartum depression (PPD). The most common drug associated with PPD was levonorgestrel (IUD with progestogen) although nine other drugs were also associated with PPD. The effect of levonorgestrel was not age related. The three drugs most commonly relate to adverse effects (eg device expulsion, pain, hemorrhage) were levonogestrel, etonogestrel and drospirenon.

The authors conclude: 'Among the drugs in the FAERS database, the use of contraceptives or an IUD with progestogen might pose a risk for PPD. We showed the potential risk of contraceptives on PPD in a real-life setting. These data will enhance the information available to nurses and clinicians in advising patients on contraception and/or treating PPD and may be useful in the management of women’s health during the early postpartum period. Considering the causality restraints of the current analysis, further epidemiological studies are recommended.


Horibe M, Hane Y, Abe J, Matsui T, Kato Y, Ueda N, Sasaoke S, Matooka Y, Hatahari H, Hasagewa S, Kinosada Y, Hara H, Nakamura M (2017) Contraceptives as possible risk factors for postpartum depression: A retrospective study of the food and drug administration adverse event reporting system, 2004–2015  Nursing Open doi: 10.1002/nop2.121

1 comment:

  1. Clinical Trial for Healthy Women 18-40
    The Clinical Research Center at EVMS is conducting a clinical trial looking at two intrauterine devices, one approved and one experimental, for contraception.
    Pre-menopausal women ages 18-40 who are generally healthy, sexually active, at risk for pregnancy, and are not at risk for sexually transmitted infections may qualify.
    For more details please visit: Study Scavenger Women's Health Study
    #Norfolk #Richmond #VA